Additional System Center tools and components for managing infrastructure, applications, and services
The issue is related to the VC++ x64 redistributable. If you have a later version than the original DPM 2025 distribution of 14.32.31326.0, the update will fail. For example, my system has 14.44.35211.0 installed and is failing. I've also tried to upgrade to 14.50 with the same failure.
I truly believe Microsoft tests NOTHING today. This should have been caught before releasing.