You're not alone—many Outlook for Mac users (including myself) have recently reported that their email signature is being automatically inserted into calendar events, and unfortunately, there is currently no built-in setting to disable this behavior independently from email signature settings.
As of July 2025, Microsoft has not yet released a fix or toggle for this behavior in Outlook for Mac
It’s being tracked as a known issue, and users are encouraged to report it to help prioritize a fix.